The population genetics of structural variants in grapevine domestication
Sep 1, 2019·,,
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1 min read
Yongfeng Zhou
Andrea Minio
Mélanie Massonnet
Edwin Solares
Yuanda Lv
Tina Beridze
Dario Cantu
Brandon S. Gaut
Abstract
Structural variants (SVs) are a largely unexplored source of genetic variation in plants. Here, we analyse 50 genomes of wild and cultivated grapevines to characterize SV diversity and its consequences. Our analyses support a reduction in the proportion of deleterious protein-coding SVs during domestication, which suggests a history of selection against deleterious structural changes. We examine the population genetics of SVs across genes and non-coding regions and find that grapevine SV diversity is shaped by demography, purifying selection and positive selection.
Type
Publication
Nature Plants
This landmark study in Nature Plants (Impact Factor ~15) represents one of the most comprehensive analyses of structural variant diversity in crop plants. The work revealed how domestication has shaped the landscape of structural genetic variation in grapevine, providing insights applicable to crop improvement efforts worldwide.
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Edwin Solares
(he/him)
Lecturer in Computer Science & Data Science
I am a computational biologist and data scientist bridging artificial intelligence,
evolutionary genomics, and climate-resilient agriculture. My research leverages
cutting-edge machine learning and bioinformatics to address global food security
challenges in the face of rapid climate change. With publications in high-impact
journals including Nature Plants, PNAS, and Genome Research (h-index: 7), I develop
tools and methods that advance both computational science and real-world applications.
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