Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing
Oct 1, 2018·
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1 min read
Edwin Solares
Co-first author
,Mahul Chakraborty
Danny E. Miller
Stefan Kalsow
Kate Hall
Anoja G. Perera
J.J. Emerson
Abstract
We developed a rapid, low-cost approach to assemble the Drosophila melanogaster reference genome using low-coverage, long-read sequencing. This methodology reduces costs by approximately 90% while maintaining high assembly quality, democratizing genomics research for labs with limited resources.
Type
Publication
G3: Genes|Genomes|Genetics
This highly-cited paper in G3: Genes|Genomes|Genetics enabled large-scale population genomics studies and made genome assembly accessible to smaller research groups worldwide.
Impact:
- 90% cost reduction compared to traditional methods
- Methodology adopted by research groups globally
- Foundational for subsequent comparative genomics work
- Demonstrated feasibility of high-quality assemblies with minimal sequencing
Authors
Edwin Solares
(he/him)
Lecturer in Computer Science & Data Science
I am a computational biologist and data scientist bridging artificial intelligence,
evolutionary genomics, and climate-resilient agriculture. My research leverages
cutting-edge machine learning and bioinformatics to address global food security
challenges in the face of rapid climate change. With publications in high-impact
journals including Nature Plants, PNAS, and Genome Research (h-index: 7), I develop
tools and methods that advance both computational science and real-world applications.
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